CXCL8 and neoplasm: For example, tumor size, tumor growth, and tumor cell line development (Fig. 4C2, 3, and 5, respectively) are associated with progression, as are the complement activation classical pathway (Fig. 4A4), IL-8 signaling, the Th2 pathway, the STAT3 pathway, the Th1 and Th2 activation pathways and T helper cell differentiation (Fig. 4B5, 8, 12, 13, and 15, respectively)30–34.