Interestingly, some of the regulated CDP phosphosites were found to be mutated in cancer tissues (e.g., NPM1 S125, PL (log2FC = 2.2), RL (log2FC = 2.04), SP (log2FC = 2.58)38) or are known to have a functional role in protein–protein interactions (e.g., HMGA1 T53, Dyrk2 KR (log2FC = 1.05), PL (log2FC = 1.21), and SX (log2FC = 1.14))39,40 (Supplementary Table 2). Here, NPM1 is linked to cancer.