Both AP–MS and BioID–MS analyses showed that the truncated Dyrk2-mutant (Dyrk2 SX), the non-cancer-related, catalytically inactive mutant (Dyrk2 KR) and the recurrently mutated Dyrk2 RL, which bears a mutation close to the activation loop, resulted in the most pronounced dissociation from the EDVP complex subunits (Fig. 4a). Here, DYRK2 is linked to cancer.