p-value ≤ 0.05) upon mutation or deletion of DYRK2. Consistent with its impact on CDP interactions, Dyrk2 SX caused the strongest effect on the phosphorylation of CDPs, together with another cancer-related Dyrk2 point mutant (Dyrk2 PL) (Fig. 7d). This evidence concerns the gene DYRK2 and cancer.