Accordingly, the SX mutant produced the strongest impact on the interaction with CDPs of the Dyrk2 interactome, followed by Dyrk2 RL; on the other hand, the KR mutant, which has not been associated with cancer, showed a rather weak effect contrary to its sizable effect on the global Dyrk2 interactome as a whole (Fig. 4d). This evidence concerns the gene DYRK2 and cancer.