SBF2 and pachyonychia congenita: In addition, the lncRNA SBF2-AS1 was shown to be involved in gemcitabine resistance in PC and the underlying mechanism was that SBF2-AS1 acted as a competing endogenous RNA (ceRNA) to sponge miR-142-3p to suppress the expression of miR-142-3p and counteract the inhibition of TWF1, which could modulate drug sensitivity [11].