HUWE1 and nervous system disorder: Furthermore, based on KEGG and Autophagy Database (http://www.tanpaku.org/autophagy/) analyses, 24 proteins involved with phagosome and autophagy pathways were detected in the SMCR8 interactome, including proteins linked with neurological diseases (CDK5, DYNC1H1, HUWE1, PPP2R1A, RANBP2, STUB1, TUBB3, TUBB4A, and USP9X; Tables 1, 2, S2).