Six out of 17 (Ro60/SSA, Ro52/SSA, PMScl100, La/SSB, U1-RNP-C, and CENPB) were detected at significantly higher frequencies in RA compared to controls, with antibodies against Ro60/SSA and Ro52/SSA as the most common, both with a frequency of 5.3% in anti-CCP2-negative RA and 4.8% and 3.4%, respectively, in anti-CCP2-positive RA. The gene discussed is TRIM21; the disease is rheumatoid arthritis.