Now we focused the analysis on the traditionally defined “seronegative” subset of EIRA, i.e. anti-CCP2 IgG−/IgM RF− patients (n = 534), and found anti-CarP antibodies in 15.9%, ACPA fine-specificities in 29.8%, and IgA and/or IgG RF in 9.4%, with a co-occurrence of at least two types of RA-associated autoantibodies in 9.6% (Table 3). The gene discussed is CD40LG; the disease is rheumatoid arthritis.