BCL2L1 and Thrombocytopenia: The ability to combine DT2216 with ABT199 in vivo suggests that DT2216 could be used in many different combinations to synergistically increase TCL killing without inducing thrombocytopenia, which cannot be achieved by the use of either Bcl-xl-specific inhibitors such as A-1155463 or the Bcl-xL/2-dual inhibitor ABT263 because Bcl-xL is essential for platelet survival and these inhibitors causes severe thrombocytopenia [33].