The term “chronic kidney disease-mineral bone disorder” (CKD-MBD) has been used in humans and animals to describe a condition characterized by renal osteodystrophy and abnormal mineral metabolism with high levels of serum phosphate, fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH) [4–6]. The gene discussed is PTH; the disease is renal osteodystrophy.