In training cohort, there were 61 lupus patients and 98 age, sex‐matched healthy controls, and serum levels of MASP2 were significantly higher in lupus patients as compared to that in controls (12 230.52 ± 779.65 vs 7174.45 ± 999.45 pg/mL, P < .001, Figure 1). The gene discussed is MASP2; the disease is systemic lupus erythematosus.