Future studies with renal biomarkers of glomerular and tubular injury such as fractional excretion of IgG and IgM and urine neutrophil gelatinase‐associated lipocalin (NGAL) alongside trending of UPCR in dogs with AKI over time might help determine the origin of this proteinuria and could have consequences of the choice of antihypertensive therapy. The gene discussed is LCN2; the disease is acute kidney injury.