Recently, a novel mechanism of drug resistance of tumour to ICI therapy has been revealed by Zhao et al. that PD-1 could be co-expressed with PD-L1 on tumour cells and tumour-infiltrating APCs, different from the conventional concept of PD-1 on T cells and PD-L1 on tumour cells and the co-expressed PD-1 could bind to PD-L1 in cis on tumour cells [90]. The gene discussed is CD274; the disease is neoplasm.