AGT and severe acute respiratory syndrome: Like other CoVs, SARS-CoV-2 uses the angiotensin-2 receptor (ACE2) to enter the target cells, but with a higher affinity for ACE2.3 After binding to its receptor, ACE2 activates the renin–angiotensin system (RAS), which leads to a downregulation of ACE2 expression, resulting in an increase in angiotensin II (Ang II) and a decrease in its counterpart angiotensin.1, , , , , –7 In contrast to SARS-CoV infection, however, SARS-CoV-2 infection seems less likely to be fatal.