Early studies found that SFRP4 overexpression was associated with a decreased rate of proliferation, decreased anchorage-independent growth, and decreased invasiveness in PC-3 and LNCaP cancer cells [16, 17], and that membranous SFRP4 expression was associated with good prognosis in 229 clinical prostate cancer specimens [16]. This evidence concerns the gene SFRP4 and prostate cancer.