While we found a mechanism by which stroke elevates ZNF216 gene expression, via PARP‐1 and could not find the binding activity of FoxO1 or FoxO3a on Atrogin‐1 and MuRF‐1 promoters, the mechanisms by which SirT1 prevents Atrogin‐1 and MuRF‐1 gene expression, and how stroke represses SirT1 gene transcription is yet to be discovered. Here, SIRT1 is linked to stroke disorder.