Both patient cohorts had very similar overall presentations and biochemical findings; discernible differences encountered included the higher percentage of leucocytosis seen with native joint sepsis (66.9% vs 52.9% in PJI group; p= 0.024) together with higher median WCC and CRP values when compared to the PJI cohort; (WCC 12.2×109/L vs 10.2×109/L respectively; p= 0.001; CRP 159.5mg/L vs 68.7mg/L respectively; p= <0.001). Here, CRP is linked to juvenile polyposis syndrome.