Recently, Hanna Kazazian N. and colleagues described in their paper a possible implication of TLR7 signalling in high-fat diet (HFD)-induced metabolic syndrome and exacerbation of lupus autoimmunity in a mouse model of lupus, the TLR8-deficient (TLR8ko) mice.10 This mouse spontaneously develops lupus-like disease due to increased TLR7 signalling by dendritic cells (DCs). Here, TLR7 is linked to systemic lupus erythematosus.