Toll-like receptors (TLRs) have been recently emerged as main actors in this pantomime playing a role linking inflammation, obesity and insulin resistance, both in humans and in murine models.6 Among TLRs, some have been specifically evaluated in the context of obesity, such as TLR2, TLR6, and TLR7 that showed a lower expression after a high fat diet in the adipose tissue.7 This evidence concerns the gene TLR6 and obesity due to melanocortin 4 receptor deficiency.