IL6 and endothelial dysfunction: It includes several risk factors such as central obesity, insulin resistance, dyslipidaemia, increased blood pressure, and endothelial dysfunction.4 The tissue possibly responsible for these events is the white adipose tissue that becomes dysfunctional and produces excessive amounts of pro-inflammatory soluble mediators including interleukin 6 (IL-6), and adipokines such as leptin, adiponectin, and resistin.5