In our study, miR-149-5p resulted downmodulated in KRAS mutated samples vs wild type; it has been demonstrated that LncRNA PCAT-1 regulated cell proliferation, invasion, migration, and apoptosis in colorectal cancer through targeting miR-149-5p [56], and according to our results, miR-149-5p resulted downregulated in CRC, likely acting as a tumor suppressor in CRC [57]. The gene discussed is KRAS; the disease is colorectal cancer.