In this exploratory study, we analyzed a cohort of 39 samples representing 13 peritumoral and 26 tumoral tissues from surgical specimens of CRC patients, in order to identify a specific miRNAs molecular signature of CRC able to discriminate PT tissues from CRC tissues and CRC KRAS mutated tissues from CRC wild type tissues, by analyzing 84 candidate miRNAs by qPCR array. This evidence concerns the gene KRAS and colorectal carcinoma.