Further analysis of circRNAs differentially expressed in B-cell precursors of ALL pediatric patients found upregulated circPVT1, circHIPK3, and circPAX5. The PAX5 (paired box protein five) gene encodes transcription factor BSAP (B-cell-lineage-specific activator protein), with a key role in defining and maintaining B-cell identity. This evidence concerns the gene PAX5 and acute lymphoblastic leukemia.