Using patient samples, Guarnerio et al. (2016) found that the rearrangement of chromosomes led to the biogenesis of fusion-circRNAs (f-circRNAs) and identified two tumor-promoting f-circRNAs, f-circPR, and f-circM9, derived from the fusion transcripts PML-RARA and MLL-MLLT3 (AF9), respectively. This evidence concerns the gene MLLT3 and neoplasm.