FGFR2 and breast neoplasm: Patients with FGFR2-overexpressing breast tumors display poor survival when treated with lapatinib, a tyrosine kinase receptor inhibitor for EGFR and HER2 suggesting that FGFR2 signaling could be maintaining the self-renewal and differentiation capabilities of breast cancer stem cells (BCSCs) in the context of lapatinib treatment (Sridharan et al., 2019).