Adipose tissue expresses components of the renin-angiotensin system (RAS) (7), including the expression of angiotensin-converting enzyme 2 (ACE2–the functional receptor for SARS-CoV), which is up-regulated in the adipocytes of subjects with obesity, turning adipose tissue into a potential target and viral reservoir. Here, ACE2 is linked to obesity due to melanocortin 4 receptor deficiency.