A prediction model using a combination of the independent risk factors, including serum sB7-H3 (day 7), IL-18 (day 14), electrolyte disturbances, hs-PDA, the age that infants achieved 120 kcal/kg.d via enteral feeding ≥40 days after birth, and NCIS, had an AUC value of 0.960, sensitivity of 86.70% and specificity of 97.60%. This evidence concerns the gene IL18 and Patent ductus arteriosus.