Firstly, the SEER database does not include information about tumor markers, such as MGMT (O (6)-methylguanine-DNA methyltransferase) promoter methylation (33) and IDH (isocitrate dehydrogenase) mutation (34), and the two markers have strong prognostic value in patients with glioblastoma. The gene discussed is IDH3A; the disease is glioblastoma.