In the current study, we explored the potential mechanism of Porf-2 in tumor cell migration by screening several key proteins, such as adhesion molecules (ICAM1, VCAM1, E-cadherin), chemokines (CCL4, CXCL4) and their receptors (CXCR4/6/7), integrins (integrin α1/β1/β3), and MMPs (MMP-2/3/7/9). Here, CCL4 is linked to neoplasm.