AGT and hypertensive disorder: Pons et al. [32] found the downregulation of matrix metalloproteinase-2 (MMP-2) and its key regulator, MMP-14, in Ang II pretreated mice and ARPE-19 cells by candesartan, providing a better understanding of the molecular events by which ARBs help delay the progression of sub-RPE deposits in AMD patients with hypertension.