SII was significantly associated with lymphocyte count (p = 0.002), neutrophil count (p < 0.001), platelet count (p < 0.001), depth of tumor (p = 0.002), lymph node metastasis (p = 0.047), pTNM stage (p = 0.001), CRP level (p < 0.001), NLR (p < 0.001), PLR (p < 0.001), and postoperative complications (p = 0.024) (Table 3). This evidence concerns the gene CRP and neoplasm.