In patients without inflammation, 274 patients (78.3%) were classified into the low SII group and the remaining 76 patients (21.7%) were classified into the high SII group; the SII was significantly associated with ASA-PS (p = 0.044), WBC (p < 0.001), lymphocyte count (p < 0.001), neutrophil count (p < 0.001), platelet count (p < 0.001), tumor size (p = 0.015), CEA (p = 0.041), CRP (p = 0.014), NLR (p < 0.001), and PLR (p < 0.001). This evidence concerns the gene CEACAM5 and neoplasm.