Since DR3.IFN-γ° mice had the highest survival and lowest gut pathology, while DR3.IL-17° mice had the lowest survival and highest gut pathology, we can infer that IFN-γ-mediated gut failure likely plays a lethal role in SAg-induced CRS and that IL-17A protects from IFN-γ-mediated gut pathology. Here, IFNG is linked to congenital rubella syndrome.