Further, liver fibrosis and non-alcoholic steatohepatitis (NASH) lead to the accumulation of liver resident IgA+PD-L1+IL-10+ cells that directly impair CTL/CD8+ T cell functions against tumor-associated antigens, resulting in the development of hepatocellular carcinoma (HCC) (127). This evidence concerns the gene CD274 and metabolic dysfunction-associated steatohepatitis.