This inhibition was only observed in TSH dependent thyrocytes and ML-1 cells derived from a human follicular carcinoma line with a high expression of TSHRs (75% expression of cell surface TSHR as established by flow cytometry) (Figure 6A) or FTC 236 cells, another follicular carcinoma line which totally lacks cell surface TSHR (Figure 6B), did not respond to MSq1 actions (Figures 6C,D). Here, TSHR is linked to thyroid gland follicular carcinoma.