In addition, ACY-241 can enhance anti-MM tumor immune activity by increasing the expression of surface antigens B7 and MHC on dendritic cells and MM cells, promoting the proliferation of CD4+/CD8+ T cells and reducing the number of MM cells, regulatory T cells, and myeloid-derived suppressor cells (Bae et al., 2018; Imai et al., 2019). This evidence concerns the gene HLA-C and Miyoshi myopathy.