EGFR and lung cancer: Furthermore, the recombinant LZ-8 (rLZ-8) induced the degradation of epidermal growth factor receptor (EGFR) in a clathrin-mediated, endocytosis-dependent, and c-Cbl ubiquitination-dependent manner, which in turn, inhibited proliferation and promoted apoptosis of lung cancer cells (Lin et al., 2017).