Among them, CYR61/CCN1 and CTGF/CCN2 have been demonstrated to be involved in the invasiveness of glioma cells, which is consistent with the research result that knockdown or silencing of CYR61/CCN1 and CTGF/CCN2 hampers the invasive phenotype (Lee et al., 2016; Figure 3). This evidence concerns the gene CCN2 and central nervous system cancer.