Due to the activation of Mst1 in HD, the phosphorylation of YAP increases, which induces mutations in the Huntington gene via excitotoxicity and calcium signal disturbances, mitochondrial dynamics changes, transcriptional interference, cytoskeletal disruption, and improper protein processing (Morrison, 2009; Mueller et al., 2018). The gene discussed is MST1; the disease is Huntington disease.