YAP1 and Cognitive impairment: However, in the early stage of AD, including preclinical AD, mild cognitive impairment, or ultra-early stage of AD, YAP deprivation mediates Hippo pathway-dependent necrosis via intracellular Aβ, which is similar to that induced by YAP cytoplasmic retention in mutant Huntington gene (Mao et al., 2016) and differs from the apoptosis belonging to type II cell death.