SETD1A and Intellectual disability: However, considering our results and the frequency of mutations in these genes in cases of intellectual disability, autism, epilepsy and schizophrenia (O'Donnell-Luria et al., 2019; Singh et al., 2016; Hiraide et al., 2018), it is tempting to hypothesise an evolutionarily conserved role for KMT2F and KMT2G in nervous system development, which deserves further investigation.