The predicted regulators, including C-C chemokine receptor (CCR2), peroxisome proliferator-activated receptor gamma coactivator (PPARGC1A), nuclear receptor (NR1I3) and peroxisomal acyl-CoA oxidase (ACOX1), might be biomarker candidates in liver cancer, but needs more biological validation in the future work. The gene discussed is NR1I3; the disease is liver cancer.