Ingenuity Pathway Analysis of the ChIP-seq data showed that Oct4 putative targets in SMC were enriched for genes involved in pluripotency, cancer, and migration, whereas Klf4 putative targets in SMC were enriched for genes involved in leukocyte recruitment, actin regulation, and extracellular matrix organization (Figure IIIA–IIID in the Data Supplement, and example of ChIP-seq peaks, Figure III I and IIIJ in the Data Supplement). The gene discussed is POU5F1; the disease is cancer.