MAPT and Alzheimer disease: In the context of AD, miR-125b is overexpressed, reducing the expression of dual-specific phosphatase 6 (DUSP6), protein phosphatase 1 catalytic subunit alpha isoform (PPP1CA), and B-cell lymphoma 2-like protein 2 (Bcl-W), resulting in the increase of p35, cdk5, and p44/42- mitogen-activated protein kinase (MAPK) signaling, hyperphosphorylation of Tau protein, and neurotoxicity, contributing to cognitive deficits in AD [173].