MAPT and Alzheimer disease: Similarly, overexpression of miR-146a in both in vitro (SH-SY5Y cells treated with Aβ1-42) and in a transgenic mouse model of AD suppressed the expression of rho-associated, coiled-coil-containing protein kinase 1 (ROCK1), reducing the phosphatase and tensin homologue (PTEN) phosphorylation, which contributes to GSK3 phosphorylation, finally promoting an exacerbation of phosphorylation of Tau protein.