Resistance training in 3xTg-AD mice also reduced the accumulation of Aβ and Tau protein, reduced expression of TNF-α and IL-1β, increased expression of IL-6, IL-10, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and fibroblast growth factor 21 (FGF-21), increased the expression of structural synaptic proteins, and improved cognitive function. Here, FGF21 is linked to Alzheimer disease.