While migratory cDCs allow for the shuttling of tumor cargo, which was potentially acquired via the specialized cDC1 receptor for necrotic material CLEC9A, to the tumor-draining lymph nodes facilitating initial T cell priming, tumor-located cDC1 enable the reactivation of cytotoxic CD8+ T cells within the tumor [41,613,617,622]. The gene discussed is MPPE1; the disease is neoplasm.