A study by Kreutz et al. revealed that cross-linking of αDEC205 targeting antibodies with the model antigen OVA and CpG-mimicking oligodeoxynucleotides (ODNs) was more efficient in priming cytotoxic CD8+ T cell responses than parallel administration of soluble ODNs and led to robust anti-tumor immune responses in the murine B16 melanoma model [742]. Here, CD8A is linked to neoplasm.