However, since the kind of environmental cue, in this case simulated by an adjuvant, is decrypted by DCs to polarize adequate T cells, adjuvants can be exploited to facilitate the induction of cytotoxic CD8+ T cells and Th1 cells, while hindering the induction of Th2 and Th17 responses, which are either unproductive or detrimental in the context of anti-tumor immunity. The gene discussed is CD8A; the disease is neoplasm.