POT1 and B-cell chronic lymphocytic leukemia: Among all, POT1 has been reported to be one of the most commonly mutated genes with recurrent mutations observed in familial melanoma, glioma, CLL, mantle cell lymphoma, cardiac angiosarcoma in Li Fraumeni like syndrome, colorectal cancer and Hodgkin lymphoma [79,80,81,82,83,84,85,86,87].