Several groups have shown that TRF1, TRF2, RAP1, POT1, and TIN2 are highly overexpressed in hepatocellular carcinoma, lung adenocarcinoma, gastric carcinoma, leukemia, renal cell carcinoma, prostate cancer and suggested their role in promoting cancer [55,56,57,58,59,60,61,62,63,64,65]. This evidence concerns the gene TERF1 and cancer.