The presence of anti-Ro/SSA and anti-La/SSB antibodies was initially related to patients with Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE), but further studies have proven that anti-Ro antibodies can be detected in many other autoimmune diseases [12,13,14,15,16,17]. Here, TRIM21 is linked to systemic lupus erythematosus.