Sorafenib is an oral tyrosine kinase inhibitor (TKI) that targets kinases involved in angiogenesis and tumor proliferation pathways implicated in the molecular pathogenesis of HCC (i.e., Raf-1, B-Raf, vascular endothelial growth factor receptor 1–3, and platelet-derived growth factor receptor β) [9]. The gene discussed is RAF1; the disease is neoplasm.