ERBB2 and breast neoplasm: In addition to liver cancer, gene expression analyses of breast tumor showed that among four different subtypes—luminal A, luminal B, HER2-positive, and triple-negative breast cancer (TNBC)—the transcript levels of ACOX1 were highest in the HER2-positive tumors and lowest in TNBC, and that higher ACOX1 transcript levels were correlated with low overall survival for HER2-positive patients [62].