BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Additionally, Liao and colleagues [72] found that USP10 can promote leukemic cell proliferation by deubiquitinating and stabilizing the S-phase kinase-associated protein 2 (SKP2) that acts as a co-regulator of BCR-ABL mediating its K63-linked ubiquitination and activation in CML cells [72].