RAG2 and neoplasm: Immunocompromised hosts, such as severely compromised immune-deficient (SCID) mice, non-obese diabetic (NOD)–SCID mice, athymic nude mice, recombination-activating gene 2 (Rag2)-knockout mice, and the NOD/SCID/IL2Rγc−/− mice, are frequently used to generate the PDX model of BC [114], as they allow tumor engraftment.