Interestingly, the authors showed that postmortem PD brain samples display increased astrocytic senescence (positive for p16INK4a, matrix metalloprotease 3 -MMP3- and the proinflammatory cytokines IL6, IL1α and IL8, and with reduced nuclear levels of LMNB1), strongly suggesting that senescent astrocytes contribute to the development of sporadic PD [76]. Here, IL6 is linked to Parkinson disease.