Using lncRNA PCR arrays to analyze PBMCs from patients with MS, Fenoglio and colleagues identified a generalized dysregulation of lncRNA expression, including lncRNAs MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), MEG9 (maternally-expressed 9), NRON (noncoding repressor of NFAT (nuclear factor of activated T cells)), ANRIL (CDKN2B antisense RNA 1), TUG1, XIST (X-inactive specific transcript), SOX2OT (SOX2 overlapping transcript), MIAT (myocardial infarction-associated transcript), HULC (hepatocellular carcinoma-associated transcript 1), and BACE-1AS (BACE1 antisense RNA). The gene discussed is MALAT1; the disease is myeloid sarcoma.