SETD2 mutations appear to be rare in primary thyroid cancers: they were found in one (1.8%) of the 56 HCCs studied by Ganly et al. [8] and one (0.9%) of the 117 PDTC-ATCs investigated by Landa et al. [14]. This evidence concerns the gene SETD2 and Ehlers-Danlos syndrome, musculocontractural type.