To determine whether the clinical resemblance reflected similarities between the mutational profiles of the two patients’ HCCs, we analyzed primary and metastatic tumor tissues from the second patient (TISS-P2.P and P2.M) using the custom NGS panel that included SETD2 and several well-known thyroid cancer-associated genes [16,17]. The gene discussed is SETD2; the disease is thyroid gland carcinoma.