PPARA and familial dilated cardiomyopathy: Given the similarity of function between PGC-1α and PGC-1β in the context of biogenesis [44,76], and the fact that SIRT1 interacts with PPARα in the setting of cardiac metabolic dysregulation [77], and that resveratrol exerts many of its beneficial effects through SIRT1 [44,65,67], it is tempting to speculate that the SIRT1/PPARα/PGC-1β pathway is involved in the cardioprotective effects of resveratrol against DCM.