Due to the unfavorable outcome, as well as the molecular and biologic similarities shared by patients with MPN with a CMML-like phenotype and JAK2-mutated CMML, it may be justified to consider our MPN/CMML patients as a special variant of CMML called CMML with concomitant myeloid neoplasm, as we have recently proposed [29]. The gene discussed is JAK2; the disease is chronic myelomonocytic leukemia.