PTEN and non-small cell lung carcinoma: These conflicting roles of miR-374a and miR-374b were clarified in a study performed by Zhao et al. [39] in NSCLC cells, identifying dual stage-specific roles of miR-374a: suppression of cell growth, migration, invasion, and metastasis by targeting cyclin D1 (CCND1) in early-stage NSCLC while also targeting PTEN in advanced-stage NSCLC.