For example, the analysis of reverse transcription-polymerase chain reaction (RT-PCR) data obtained from 147 patients with non-small cell lung cancer (NSCLC), the most common type of lung cancer, identified a six-gene signature (STX1A, HIF1A, CCT3, HLA-DPB1, MAFK, and RNF5) as a prognostic marker of poor patient outcomes [3]. This evidence concerns the gene RNF5 and non-small cell lung carcinoma.