ACE and aortic stenosis: Genes with greater than 15 interactions were CCR5, CCR7, CXCR3, CXCR5, CXCR6, FPR2, NPY, PF4, and PPBP. The most upregulated genes for AS were COL2A1, COL11A1, CR2, CXCL5, KCNJ6, and PF4. The most downregulated genes for AS were ADIPOQ, DGAT2, GPD1, LPL, MLXIPL, and TRDN. Several genes were identified which bridged gene clusters: ACE, ADIPOQ, CCR7, CD19, CD27, CD40LG, CD79A, FPR2, IL13, MME, and SERPINA1.