Other important upregulated genes of interest specifically involved with AS included KCNJ6 (Potassium Voltage-Gated Channel Subfamily J Member 6), and SPP1 (Secreted Phosphoprotein 1, or Osteopontin), which is involved in osteoclast attachment to the mineralized bone matrix [36]. This evidence concerns the gene KCNJ6 and aortic stenosis.