SERPINF1 and neoplasm: Other anti-angiogenic factors that were overexpressed by the AAV vector system to decrease tumor growth in animal models were vastatin, an anti-angiogenic polypeptide, in a rat HCC model [152], human plasminogen kringle domains by AAV8 vectors in murine melanoma models, and pigment epithelium-derived factor (PEDF) in various models [153,154,155,156,157].