Mechanistically, miRNA-7 expression in glioblastoma cells resulted in downregulation of the growth-promoting Epidermal Growth Factor Receptor (EGFR) pathway, upregulation of the death receptor pathways and consequently enhanced TRAIL-mediated apoptotic cell death both in vitro and in vivo leading to tumor growth inhibition [108]. The gene discussed is TNFSF10; the disease is glioblastoma.