In an APCmin/+ murine model, it was demonstrated that the oral administration of IL-10 encapsulated in microparticles reduces polyposis and increases the survival rate, apparently this controversial IL-10 effect can be explained given that IL-10 has a neutralization effect over Foxp3+RORγt+IL-17+ Treg cells that promote the disease and a positive effect on the restauration of Foxp3+RORγt−IL-17− Treg cells, which are protective (Figure 2C) [73]. The gene discussed is IL10; the disease is polyposis.