CXCR3 and colorectal carcinoma: CXCR3 and its ligands are differentially expressed at sites of inflammation and within the CRC tumors; CXCR3 is functionally expressed on Treg cells and also induces the differentiation of peripheral T cells into Treg cells, suggesting that a CXCR3 molecule could be an indirect Treg cell target with therapeutic potential during CRC [72].